Numba

Numba is an Open Source NumPy-aware optimizing compiler for Python sponsored by Continuum Analytics, Inc. It uses the LLVM compiler infrastructure to compile Python syntax to machine code.

It is aware of NumPy arrays as typed memory regions and so can speed-up code using NumPy arrays. Other, less well-typed code will be translated to Python C-API calls effectively removing the "interpreter" but not removing the dynamic indirection.