孤束核（英文：Nucleus of the solitary tract，缩写：NTS）是延髓灰质内的一组柱状神经核。于孤束核内的神经纤维称为孤束，包括从颜面神经、舌咽神经和迷走神经导入的一般内脏感觉神经纤维和味觉纤维。孤束核发出纤维投射至脑部其他区域，包括网状结构、副交感神经节前神经元、下丘脑和丘脑，参与形成 自主神经调控的回路。孤束核内的细胞根据不同功能分布。例如接受味觉的细胞位于神经核前上部分，而参与调控心血管和呼吸功能的细胞位于孤束核的下后部分。

In the human brain, the solitary nucleus (nucleus of the solitary tract, nucleus solitarius, nucleus tractus solitarii, NTS) is a series of nuclei (clusters of nerve cell bodies) forming a vertical column of grey matter embedded in the medulla oblongata. Through the center of the NTS runs the solitary tract, a white bundle of nerve fibers, including fibers from the facial, glossopharyngeal and vagus nerves, that innervate the NTS. The NTS projects to, among other regions, the reticular formation, parasympathetic preganglionic neurons, hypothalamus and thalamus, forming circuits that contribute to autonomic regulation. Cells along the length of the NTS are arranged roughly in accordance with function; for instance, cells involved in taste are located in the higher, more forward ("rostral") part, while those regulating cardio-respiratory and gastrointestinal processes are found in the lower, more posterior ("caudal") part.