核孔蛋白（英语：nucleoporins）是一类蛋白质家族，作为构成核孔复合物的砖块。核孔复合物是长度纵穿整个核被膜的巨大结构物，形成了细胞核与细胞质之间调控高分子流动的峡口。核孔蛋白家族包含了50～100种蛋白质，是真核细胞核孔复合物的主要构成部分。核孔可允许水溶性分子转运穿过核被膜。

该家族包含的蛋白质根据其分子量（千道）而得名，列表：

The nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex (NPC). The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the cell nucleus and the cytoplasm. Nuclear pores in turn allow the transport of water-soluble molecules across the nuclear envelope. Nucleoporins, a family of around 30 proteins, are the main components of the nuclear pore complex in eukaryotic cells. Nucleoporin 62 is the most abundant member of this family. Nucleoporins are able to transport molecules across the nuclear envelope at a very high rate. A single NPC is able to transport 60,000 protein molecules across the nuclear envelope every minute.