| 单词 | NMDAR |
| 释义 |
NMDAR
中文百科
N-甲基-D-天门冬胺酸受体 NMDA receptor（重定向自NMDAR）
  ![一个NMDA受体的示意图。麸胺酸盐会与麸胺酸盐结合位结合，而甘胺酸会与甘胺酸结合位结合。而会造成抑制受体活性的异位并没有被占据。NMDA受体需要有两分子麸胺酸盐或天门冬胺酸，与两分子甘胺酸进行结合[1]。](/uploads/202501/29/Activated_NMDAR4137.PNG)  N-甲基-D-天门冬胺酸受体（英语：N-methyl-D-aspartate receptor，简称NMDA受体或NMDAR）为麸胺酸盐受体，是一个主要的分子设备，控制突触的可塑性与记忆功能。 NMDA受体是一种离子型麸胺酸盐受体的特别型态。NMDA（N-甲基-D-天门冬胺酸）是一种选择性致效剂，可以与NMDA受体结合，但是无法和其他麸胺酸盐受体结合。NMDA受体的结合，会导致离子信道非选择性地开启，使阳离子通过，进而使平衡电位改变至接近0毫伏特。NMDA受体进行活化，必须依赖电压，这会导致离子信道会阻挡细胞外的Mg与Zn离子通过，并允许Na离子与少量Ca离子流入细胞，以及使K离子流出细胞，并保持电压的依赖性。
英语百科
NMDA receptor N-甲基-D-天门冬胺酸受体（重定向自NMDAR）
 ![Stylised depiction of an activated NMDAR. Glutamate is in the glutamate-binding site and glycine is in the glycine-binding site. Allosteric sites that would cause inhibition of the receptor are not occupied. NMDARs require the binding of two molecules of glutamate or aspartate and two of glycine.[1]](/uploads/202501/29/Activated_NMDAR4138.PNG) 4138.jpg) The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function. |
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