Nicotinic acid adenine dinucleotide phosphate

Ball-and-stick model of the NAADP molecule

Cell stimuli select different Ca2+ stores by synthesising different second messengers. Shown for comparison are the ER-targeting messengers, IP3 and cADPR.

Speculative pathways for NAADP synthesis and degradation. ADP-ribosyl cyclase (ARC) family members (such as CD38) can synthesise NAADP via the base-exchange reaction (NicAcid, Nicotinic Acid; NiAm, nicotinamide). NAADP may be broken down to NAAD via a Ca2+-sensitive phosphatase, or to 2-phosphoadenosine diphosphoribose (ADPRP) by CD38 itself. For simplicity, enzyme topology has been ignored (see below).

Nicotinic acid adenine dinucleotide phosphate, (NAADP), is a Ca-mobilizing second messenger synthesised in response to extracellular stimuli. Like its mechanistic cousins, IP₃ and cyclic adenosine diphosphoribose (Cyclic ADP-ribose), NAADP binds to and opens Ca channels on intracellular organelles, thereby increasing the intracellular Ca concentration which, in turn, modulates sundry cellular processes (see Calcium signalling). Structurally, it is a dinucleotide that only differs from the house-keeping enzyme cofactor, NADP by a hydroxyl group (replacing the nicotinamide amino group) and yet this minor modification converts it into the most potent Ca-mobilizing second messenger yet described. NAADP acts across phyla from plants to man.

单词	Nicotinic acid adenine dinucleotide phosphate
释义	Nicotinic acid adenine dinucleotide phosphate 英语百科 Nicotinic acid adenine dinucleotide phosphate Nicotinic acid adenine dinucleotide phosphate, (NAADP), is a Ca-mobilizing second messenger synthesised in response to extracellular stimuli. Like its mechanistic cousins, IP₃ and cyclic adenosine diphosphoribose (Cyclic ADP-ribose), NAADP binds to and opens Ca channels on intracellular organelles, thereby increasing the intracellular Ca concentration which, in turn, modulates sundry cellular processes (see Calcium signalling). Structurally, it is a dinucleotide that only differs from the house-keeping enzyme cofactor, NADP by a hydroxyl group (replacing the nicotinamide amino group) and yet this minor modification converts it into the most potent Ca-mobilizing second messenger yet described. NAADP acts across phyla from plants to man.
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