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单词 nickase
释义

nickase

英汉-汉英词典
切口酶
词组 | 习惯用语
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  • nickname n. 绰号;昵称 vt. 给……取绰号;叫错名字
nickase 切口酶

网络短语:
zinc-finger nickases 锌指切口酶
nickase e 切口酶
原声例句
经济学人 Science and technology

CRISPR-Cas9 nickases, for example, are enzymes that cut only one strand of the DNA double helix.

例如,CRISPR-Cas9 切口酶是仅切割 DNA 双螺旋一条链的酶。

经济学人 Science and technology

To make genetic changes, nickases therefore need to be used in pairs, meaning less risk of off-target effects.

因此, 为了进行基因改变, 切口酶需要成对使用,这意味着脱靶效应的风险更小。

经济学人 Science and technology

At the clinical frontier is " prime editing" , which uses a Cas9 nickase along with a specially designed RNA guide that not only locates the correct region of DNA, but also carries a template of the desired change.

临床前沿是“初次编辑” ,它使用 Cas9 切口酶和专门设计的 RNA 指南, 该指南不仅可以定位正确的 DNA 区域,还可以携带所需变化的模板。

经济学人 Science and technology

It is unlikely that both nickases in an edit would bind incorrectly to the same section of DNA. Another method, " base editing" , can chemically change a single letter of a DNA's sequence into another without the need for cuts.

编辑中的两种切口酶不太可能错误地结合到同一 DNA 片段上。另一种方法是“碱基编辑”,它可以通过化学方法将 DNA 序列中的一个字母改变为另一个字母,而无需切割。

英语百科

Nicking enzyme

A nicking enzyme (or nicking endonuclease) is an enzyme that cuts one strand of a double-stranded DNA at a specific recognition nucleotide sequences known as a restriction site. Such enzymes hydrolyse (cut) only one strand of the DNA duplex, to produce DNA molecules that are “nicked”, rather than cleaved.

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更新时间:2025/6/19 2:42:36