再摄取抑制剂 (英语：reuptake inhibitor)(RI)是一种再摄取调节剂，它可抑制由细胞膜转运体中介的神经传导物再摄取，进而增加胞膜外神经传导物的浓度。达成更多神经传导. 数种药物借由再吸收抑制达到心理和生理上的作用，包括各式抗忧郁剂及兴奋剂

多数已知的再吸收抑制剂影响单胺神经传导物血清素，去甲肾上腺素(&肾上腺素)及多巴胺。 但也有不少药品及研究用化合物作用于其他神经递质，例如谷氨酸,γ-氨基丁酸 (GABA), 甘胺酸,腺咁, 胆碱 (乙酰胆碱前驱物), 及大麻素,

A reuptake inhibitor (RI) is a type of reuptake modulator which inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter and therefore an increase in neurotransmission. Various drugs to exert their psychological and physiological effects through reuptake inhibition, including many antidepressants and psychostimulants.