新橙皮苷二氢查耳酮（Neohesperidosyl dihydrochalcone, Neohesperidin DC, NHDC）是一种从天然柑橘植物中提取到的新橙皮苷氢化而成的黄酮类衍生物，是一种人工甜味剂。二氢查耳酮是一类非常重要的活性成分, 具有抗氧化、抗肿瘤、抗糖尿病、抗菌以及雌激素样作用。在欧洲已被允许作为甜味剂。1997年，新橙皮苷二氢查耳酮被中华人民共和国卫生部列入“食品添加剂使用卫生标准”增补品种，可用于食品工业。其具有强烈的甜味（是蔗糖甜度的1500~1800倍），口感清爽，余味持久，具有极佳的屏蔽苦味的功效。目前由于提炼率较低，价格昂贵，尚未广泛应用于食品行业。

Neohesperidin dihydrochalcone, sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus.

NHDC was discovered during the 1960s as part of a United States Department of Agriculture research program to find methods for minimizing the taste of bitter flavorants in citrus juices. Neohesperidin is one such bitter compound. When treated with potassium hydroxide or another strong base, and then catalytically hydrogenated, it becomes NHDC, a compound roughly 1500-1800 times sweeter than sugar at threshold concentrations; around 340 times sweeter than sugar weight-for-weight. Its potency is naturally affected by such factors as the application in which it is used, and the pH of the product.