纳米压痕技术（英：Nanoindentation），也称深度敏感压痕技术（英：Depth-Sensing Indentation, DSI)，是最简单的测试材料力学性质的方法之一，可以在纳米尺度上测量材料的各种力学性质，如载荷-位移曲线、弹性模量 (Elastic Modulus)、硬度(Hardness)、断裂韧性(Fracture Toughness)、应变硬化效应(Strain Hardening Effect)、粘弹性(Viscoelastic)或蠕变(Creep)行为等。

Nanoindentation is a variety of indentation hardness tests applied to small volumes. Indentation is perhaps the most commonly applied means of testing the mechanical properties of materials. The nanoindentation technique was developed in the mid-1970s to measure the hardness of small volumes of material.