Familial amyloid cardiomyopathy is a genetic disorder where mutant transthyretin protein, or TTR, is misfolded and prone to depositing in the heart tissue.

家族性淀粉样心肌病是一种基因疾病：突变的转甲状腺素蛋白（TTR）折叠错误，并易于在心脏组织中沉积。

Is the mutant protein getting trapped inside cells, and how does this happen?

突变蛋白是否被困在细胞内？这是如何发生的？

And in the end, we identified one compound that could specifically remove the mutant protein.

最后，我们鉴定出了一种可以特异性去除突变蛋白的化合物。

And yet our greatest insight was not our successin removing the mutant protein from these kidney cells.

然而，我们最大的洞察并不是我们成功地从这些肾细胞中去除了突变蛋白。

In preliminary studies shown here at TED for the first time, here is a mouse I cleared of mutant protein.

在TED上首次展示的初步研究中，这是我清除突变蛋白的小鼠。

After giving the drug to mice with kidney disease for one week, the mutant protein had all but disappeared from these kidneys.

给患有肾病的小鼠服用这种药物一周后，突变蛋白几乎从这些肾脏中消失了。

Sequencing can also reveal what what the MHC molecules will look like and, together with the mutant protein sequences, this can predict which neoantigens cells will display.

测序还可以揭示 MHC 分子会是什么样子，并且与突变蛋白序列一起， 这可以预测哪些新抗原细胞会显示。