现代人类多区域起源说（Multiregional origin of modern humans，又译多地起源说）是一个用来解释人类演化的科学模型。该假说认为，人类最初是在距今两百万年前的更新世初期兴起的，而且在后续的人类演化中，维持着一个单一的、连续的人类物种。这个物种涵盖了古老的人属形式，如直立人和尼安德塔人，以及现代的形式，在世界各地发生演变，成为目前不同人群的现代智人。该理论声称，人类是透过在世界各个不同区域之内的适应，再加上那些区域之间的基因流动，两相结合而发生演化。多区域起源说的支持者指出，化石证据和基因体证据支持他们的假设。

The multiregional hypothesis, multiregional evolution (MRE), or polycentric hypothesis is a scientific model that provides an alternative explanation to the more widely accepted "Out of Africa" model for the pattern of human evolution.

Multiregional evolution holds that the human species first arose around two million years ago and subsequent human evolution has been within a single, continuous human species. This species encompasses all archaic human forms such as H. erectus and Neanderthals as well as modern forms, and evolved worldwide to the diverse populations of modern Homo sapiens sapiens. The hypothesis contends that the mechanism of clinal variation through a model of "Centre and Edge" allowed for the necessary balance between genetic drift, gene flow and selection throughout the Pleistocene, as well as overall evolution as a global species, but while retaining regional differences in certain morphological features. Proponents of multiregionalism point to fossil and genomic data and continuity of archaeological cultures as support for their hypothesis.