1-甲基-4-苯基-4-哌啶丙酸酯（MPPP）是一种在1940年代由罗氏的研发人员研制出来的鸦片类止痛药。 MPPP后来在医学上并没有被使用，不过却被作为一种毒品而非法生产。它是一种哌替啶的类似物，但由于在医学上没有用途，美国缉毒局的受控物质法案将其列为了I类管制药物。实际上MPPP是哌替啶酯的羧酸部分与醇部分调转的同分异构体，被认为有相当于吗啡的70%的药效。

这种药物在1977年由一名23岁的马里兰州化学系学生巴里·金德斯顿（Barry Kidston）第一次作为毒品合成。金德斯顿当时参考了阿尔伯特·耶林的一篇论文。 通过将杜冷丁的酯结构反转，他成功制造出了MPPP这种在当时合法且不受控制的接近吗啡的药效的毒品。

Desmethylprodine or 1-methyl-4-phenyl-4-propionoxypiperidine (MPPP, Ro 2-0718) is an opioid analgesic drug developed in the 1940s by researchers at Hoffmann-La Roche. It is an analog of pethidine (meperidine) which the DEA has labeled as a Schedule I drug in the United States. Chemically, it is a reversed ester of pethidine which has about 70% of the potency of morphine. Unlike its derivative prodine, it was not reported to exhibit optical isomerism. It was reported to have 30 times the activity of pethidine and a greater analgesic effect than morphine in rats, and it was demonstrated to cause central nervous system stimulation in mice.