德纳利国家公园和自然保护区（Denali National Park and Preserve）或德那利国家公园暨保存区建于1917年2月26日，位于美国阿拉斯加州内陆，占地24,585平方公里。北美最高峰迪纳利山位于园内。园内大多属于北方的荒野。每年夏季游客增多的时候园方会提供游园公车。迪那利国家公园暨保存区也是灰熊、驯鹿、大白羊、麋鹿等大型野生动物的栖息地。

德纳利国家公园和保存区由美国国家公园管理局管理。

Denali National Park and Preserve is a national park and preserve located in Interior Alaska, centered on Denali, the highest mountain in North America. The park and contiguous preserve encompasses more than 6 million acres (24,500 km), of which 4,724,735.16 acres (19,120 km) are federally owned national park. The national preserve is 1,334,200 acres (5,430 km), of which 1,304,132 acres (5,278 km) are federally owned. On December 2, 1980, a 2,146,580 acre (8,687 km) Denali Wilderness was established within the park. Denali's landscape is a mix of forest at the lowest elevations, including deciduous taiga. The preserve is also home to tundra at middle elevations, and glaciers, rock, and snow at the highest elevations. The longest glacier is the Kahiltna Glacier. Today, 400,000 people visit the park annually. Wintertime activities includes dog-sledding, cross-country skiing, and snowmachining.