莫纳海峡（英语：Mona Passage、西班牙语：Canal de la Mona）是中美洲的海峡，位于大安地列斯群岛区域，连接大西洋和加勒比海，分隔伊斯帕尼奥拉岛和波多黎各，宽130公里，是来往大西洋和巴拿马运河之间的重要航道。

The Mona Passage is a strait that separates the islands of Hispaniola and Puerto Rico. The Mona Passage connects the Atlantic Ocean to the Caribbean Sea, and is an important shipping route between the Atlantic and the Panama Canal.

The 80 mi (130 km) stretch of sea between the two islands is one of the most difficult passages in the Caribbean. It is fraught with variable tidal currents created by the large islands on either side of it, and by sand banks that extend out for many miles from both coasts.