莫洛波河（Molopo River）是非洲南部的河流，河道全长约960公里，河水流动为间歇性。当百年一遇的洪水涌到，莫洛波河便可在座标28°31′2″S 20°12′46″E / 28.51722°S 20.21278°E / -28.51722; 20.21278流入奥兰治河。

莫洛波河是博茨瓦纳和南非接壤边界的一部分，南非城市梅富根被认为是发源地，诺索布河支流在海拔890米的地方流入莫洛波河。

The Molopo River (Afrikaans:Moloporivier) is one of the main rivers in Southern Africa. It has a length of approximately 960 kilometres and a catchment area of 367,201 km with Botswana, Namibia and South Africa sharing roughly about a third of the basin each.