米斯特克是位于墨西哥南部瓦哈卡州西部、北部及其邻接的格雷罗州(Guerrero)和普埃布拉州(Puebla)几个地区的古文明。大约与萨波特克文明同时，受奥尔梅克文明影响较大。有象形文本。

现代米斯特克人居住在高山、河谷和沿海，多数务农，耕作技术基本上是刀耕火种。种地用锄和铲，或用牛和犁。主要作物是玉蜀黍、豆类和南瓜。其他生产活动是狩猎、捕鱼、放牧和采集野生食物。缺乏生计的地方则制作和出售棕榈编织物。编织和制陶是一般手工业。他们虽然名义上信仰天主教，但大多数人是信仰一种包括天主教之前的神灵在内的混合宗教，某些地区信奉雨神。

The Mixtec /ˈmiːʃtɛk/, or Mixtecos, are indigenous Mesoamerican peoples of Mexico inhabiting the region known as La Mixteca of Oaxaca and Puebla, as well as the state of Guerrero's Región Montañas, and Región Costa Chica, which covers parts of the Mexican states of Oaxaca, Guerrero and Puebla. The Mixtec region and the Mixtec peoples are traditionally divided into three groups, two based on their original economic cast and the third on the region they settled. High Mixtecs or mixteco alto were of the upper class and generally more well-to-do, the Low Mixtecs or "mixteco bajo" were generally poorer. In recent times, an economic reversal or equalizing has been seen. The third group is Coastal Mixtecs "mixteco de la costa". This group's language is closely related to that of the Low Mixtecs, and are currently inhabiting the Pacific slope of Oaxaca and Guerrero. The Mixtec languages form a major branch of the Otomanguean language family.