Protein folding

Illustration of the main driving force behind protein structure formation. In the compact fold (to the right), the hydrophobic
amino acids (shown as black spheres) are in general shielded from the solvent.

Folding@home uses Markov state models, like the one diagrammed here, to model the possible shapes and folding pathways a protein can take as it condenses from its initial randomly coiled state (left) into its native 3D structure (right).

Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil. Each protein exists as an unfolded polypeptide or random coil when translated from a sequence of mRNA to a linear chain of amino acids. This polypeptide lacks any stable (long-lasting) three-dimensional structure (the left hand side of the first figure). Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figure), known as the native state. The resulting three-dimensional structure is determined by the amino acid sequence (Anfinsen's dogma). Experiments beginning in the 1980s indicate the codon for an amino acid can also influence protein structure.

单词	Misfolding
释义	Misfolding 原声例句经济学人-科技 Dr Drayna suspects that both conditions are caused by misfolding of the enzymes in question, but that the details are different. 德雷纳博士怀疑这两种病状都是由错误折叠酶引起，但细节有所不同。经济学人-科技 CJD and a handful of similar neurological conditions are caused by the misfolding of a particular protein that is found in the membranes of certain nerve cells. 该病以及类似的一些神经症状是由于某种神经细胞的细胞膜上的一个特殊蛋白发生错误折叠所致。英语百科 Protein folding Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil. Each protein exists as an unfolded polypeptide or random coil when translated from a sequence of mRNA to a linear chain of amino acids. This polypeptide lacks any stable (long-lasting) three-dimensional structure (the left hand side of the first figure). Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figure), known as the native state. The resulting three-dimensional structure is determined by the amino acid sequence (Anfinsen's dogma). Experiments beginning in the 1980s indicate the codon for an amino acid can also influence protein structure.
随便看	reversed expansion的意思 reversed fault的意思 reversed feedback amplifier的意思 reversed field的意思 reversed field focusing的意思 Reversed field pinch的意思 reversed film的意思 reversed filter的意思 reversed flow的意思 reversed flow condenser的意思 reversed flow of qi的意思 reversed flow region的意思 reversed flow turbine的意思 reversed flow type combustion chamber的意思 reversed fold的意思 reversed force carriage plow的意思 reversed frame的意思 reversed fusee的意思 reversed gastric tube的意思 reversed gastric tube esophagoplasty的意思 reversed gas turbine的意思 reversed geometry的意思 reversed grading的意思 reversed grease的意思 reversed hack saw blade的意思

Misfolding

Protein folding