甲羟戊酸途径（Mevalonate pathway）甲羟戊酸途径，也被称为异戊二烯途径(Isoprenoid pathway)或HMG-CoA还原酶(HMG-CoA reductase pathway)途径，是存在于真核生物，古菌和一些细菌中一个重要的代谢途径。该途径产生两种被称为五碳构件异戊二烯焦磷酸（IPP）和二甲基烯丙基焦磷酸（DMAPP），这用来产生异戊二烯，一个多样化的类，超过30,000的生物分子例如胆固醇，血红素，维生素K，辅酶Q10，及所有的类固醇激素。甲羟戊酸途径开始于乙酰-CoA，而结束于产生IPP和DMAPP。它是一类最有名降胆固醇药他汀类药物的靶标。药物立普妥（阿托伐他汀）抑制甲羟戊酸途径中HMG-CoA还原酶。截至2015年，立普妥，仍然是以1250亿美元的销售额，为全球最畅销的药物。

The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria. The pathway produces two five-carbon building blocks called isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which are used to make isoprenoids, a diverse class of over 30,000 biomolecules such as cholesterol, heme, vitamin K, coenzyme Q10, and all steroid hormones.