三叉神经中脑核（Mesencephalic nucleus of trigeminal nerve），是三叉神经位于中脑的一个感觉核团，主管脸部的肌肉的本体感觉。与许多其他周围神经系统的神经核团不同，三叉神经中脑核内的神经元不是依靠化学突触，而是依靠电突触来传递信息。该核团中的神经元是伪单极神经元，接受来自下颚的本体感觉信息，投射到三叉神经运动核，来调节下颚反射。另外中脑核也是周围神经系统中，唯一将细胞本体保留于中枢神经的初级传入神经（感觉神经），一般感觉神经的细胞核通常位于神经节中（如三叉神经节）。

The mesencephalic nucleus is involved with proprioception of the face, that is, the feeling of position of the muscles. Unlike many nuclei within the central nervous system (CNS), the mesencephalic nucleus contains no chemical synapses but are electrically coupled. Neurons of this nucleus are unipolar cells that receive proprioceptive information from the mandible and send projections to the motor trigeminal nucleus to mediate monosynaptic jaw jerk reflexes. It is also the only structure in the CNS to contain the cell bodies of a primary afferent, which are usually contained within ganglia (like the trigeminal ganglion).