门德里西奥是瑞士的城镇，位于该国南部，由提契诺州负责管辖，面积21.65平方公里，海拔高度354米，2010年人口11,582，其中八成居民信奉罗马天主教。

Mendrisio is a municipality in the district of Mendrisio in the canton of Ticino in Switzerland.

Mendrisio is the seat of the Accademia di Architettura of the university of Italian-speaking Switzerland (USI).

The municipality was boosted in size on 4 April 2004 when it incorporated the former municipality of Salorino. On 5 April 2009 it incorporated the former municipalities of Arzo, Capolago, Genestrerio, Rancate and Tremona. On 14 April 2013 the former municipalities of Besazio, Ligornetto and Meride merged into the municipality of Mendrisio.