美国大都市圈（英文：Megaregions of the United States）是指一些由美国城市组成的集群网络。据估计，这些大都市圈的人口将会于2025年增长至700万至6300万不等。而美国2050项目，一个由洛克菲勒基金会和福特基金会赞助的组织，列出了位于美国和加拿大的11个美国大都市圈。于2005年7月，维吉尼亚理工大学都市研究所的罗伯特·E·朗和当·达维尔对美国大都市圈进行了探讨，并于2007年将美国二十个大都市圈'组合成十个大都市圈。而这个概念是参考城市群概念制成的。

Megaregions of the United States are clustered networks of American cities, the population of which currently ranges or is projected to range from about 57 to 63 million by the year 2025. America 2050, an organization sponsored by the Rockefeller and Ford Foundations, lists 11 megaregions in the United States and Canada. Megapolitan areas were explored in a July 2005 report by Robert E. Lang and Dawn Dhavale of the Metropolitan Institute at Virginia Tech. A later 2007 article by Lang and Nelson uses 20 megapolitan areas grouped into 10 megaregions. The concept is based on the original megalopolis model.