迈加比佐斯（英语：Megabyzus），约活动于公元前5世纪前后，波斯阿契美尼德王朝将领。佐皮罗斯之子，薛西斯一世的姻兄弟。公元前482年他前往巴比伦平定反波斯人的叛乱，将巴比伦城洗劫一空。曾随薛西斯一世参加希波战争，公元前465年他又成为杀死薛西斯一世的阴谋者之一。新王阿尔塔薛西斯一世即位后，他担任叙利亚总督，并指挥军队进攻埃及，企图恢复波斯在埃及的统治地位。埃及叛乱头目投降后，他因为王太后的干预而食言杀死叛乱者。不久又在叙利亚发动反波斯的叛乱。后与阿尔塔薛西斯一世重归于好，但又在狩猎活动中因冒犯国王而远遁。5年后他佯病回国。在王室调解下与阿尔塔薛西斯一世和好如初。

For other historical characters named Megabyzus, see Megabyzus (disambiguation).

Megabyzus (Ancient Greek: Μεγάβυζος, calque of Old Persian Bagabuxša-, meaning "God saved") was a Achaemenid Persian general, son of Zopyrus, satrap of Babylonia. His father was killed when the satrapy rebelled in 482 BC, and Megabyzus led the forces that recaptured the city, after which the statue of the god Marduk was destroyed to prevent future revolts. Megabyzus subsequently took part in the expedition against Greece. Herodotus claims that he refused to act on orders to pillage Delphi, but it is doubtful such orders were ever given.