By 1949 better manufacturing methods allowed the price to fall to 20 cents. The use of penicillin exploded.

到1949年，更好的生产方法让价格降到了20美分。青霉素的使用激增。

The program generates possibilities based on user inputs about objectives, materials, cost restrictions, manufacturing methods, and so on.

这款程序根据用户输入的目标、材料、成本限制、制造方法等信息生成各种可能的方案。

In 1983 a more tractable manufacturing method was discovered.

1983 年，发现了一种更容易处理的制造方法。

And they've patented this design based on the same manufacturing methods that are used to make microchips today.

他们已经根据当今用于制造微芯片的相同制造方法为该设计申请了专利。