Mandanici (Sicilian: Mannanici) is a comune (municipality) in the Province of Messina in the Italian region Sicily, located about 170 kilometres (110mi) east of Palermo and about 30 kilometres (19mi) southwest of Messina. As of 31 December 2004, it had a population of 695 and an area of 11.7 square kilometres (4.5sqmi).