I think the point is made. Big point!

我想这一点已经很清楚了。很重要的一点！

He made big long loaves and tiny round loaves.

他做了许多大的长面包和小的圆面包。

She is proud of her activism but admits she made big mistakes.

她为自己的行动主义感到骄傲，但也承认自己犯了很大的错误。

They see that Voltaire made big bucks, big francs, big livre writing.

他们看到伏尔泰妙笔生财。

After years of setbacks for RSV research, drugmakers have made big improvements this year.

在呼吸道合胞病毒研究经历了多年的挫折后，制药商今年取得了重大进展。

Scientists have made big advances in understanding the human genome in the past twenty years.

在过去的二十年里，科学家们在理解人类基因组方面取得了很大的进步。

The sighting made big news, because almost all exoplanet discoveries before or since were indirect detections.

这一发现引起轰动，因为此前几乎所有系外行星的发现都是间接探测到的。

The government made big efforts to try and provide more space, converting schools into short-term shelters.

政府作出了很大努力，试图提供更多空间，将学校改造成临时避难所。

Instead, they empower themselves to make big changes.

相反，他们让自己有能力做出重大改变。

And people make big decisions that are wrong.

人们会做出错误的重大决定。

It can involve making big sacrifices.

可能涉及到很大的牺牲。

Small countries can make big stinks.

打电话给领事馆 问问他们要如何安置尸体。

Its manufacturing system was too large, and it only made big cars that the public did not want.

公司的制造系统太过庞大，且只生产公众不感兴趣的大型汽车。

There are also ways you can make big differences!

还有一些方法可以让你做出大的改变！

Make big signs. Tell everyone about the car wash.

制作大广告牌， 向大家广发洗车活动的消息。

All right, big business is making big headlines this week.

好吧, 大企业上了本周的头条新闻。

We use it with strangers or to make big requests.

我们对陌生人或在提出大的要求时会使用它。

If it succeeds, Teva's acquisition would be the biggest foreign takeover yet made by an Israeli firm.

如果梯瓦收购成功，这将成为以色列公司最大的境外并购。

But the publishers wanted him to make big changes, he refused.

出版社让他大幅修改某些地方，遭到了他的拒绝。

Studios need theaters to make big money and get big press.

电影公司需要剧院来赚大钱并获得媒体的关注。