罗马，马其顿和塞硫古战争是第二次布匿战争期间与之后由罗马在地中海东部，亚得里亚海，爱琴海发动的战争。与布匿战争一起，它们使罗马控制并影响了整个地中海。

（前214年——前205年）在第二次布匿战争时，腓力五世（马其顿）与汉尼拔结盟。由于忧虑汉尼拔的马其顿盟军，罗马派出军团跨越亚得里亚海。罗马军团与马其顿小规模冲突，并占领亚得里亚海沿岸的一些地区用于海上劫掠。罗马的目的不在于征服，而是使马其顿的希腊城邦与政治联盟分裂而消除威胁。公元前205年签订的腓尼基和约结束了战争。此次冲突打开了罗马干涉希腊之门。

The Macedonian Wars (214-148 BC) were a series of conflicts fought by the Roman Republic and its Greek allies in the eastern Mediterranean against several different major Greek kingdoms. They resulted in Roman control or influence over the eastern Mediterranean basin, in addition to their hegemony in the western Mediterranean after the Punic wars. Traditionally, the "Macedonian Wars" include the four wars with Macedonia, in addition to one war with the Seleucid Empire, and a final minor war with the Achaean League (which is often considered to be the final stage of the final Macedonian war). The most significant war was that fought with the Seleucid Empire, while the war with Macedonia was the second, and both of these wars effectively marked the end of these empires as major world powers, even though neither of them led immediately to overt Roman domination. Four separate wars were fought against the weaker power, Macedonia, due to its geographic proximity to Rome, though the last two of these wars were against haphazard insurrections rather than powerful armies. Roman influence gradually dissolved Macedonian independence and digested it into what was becoming a leading global empire. The outcome of the war with the now-deteriorating Seleucid Empire was ultimately fatal to it as well, though the growing influence of Parthia and Pontus prevented any additional conflicts between it and Rome.