The Macedonian Wars (214-148 BC) were a series of conflicts fought by the Roman Republic and its Greek allies in the eastern Mediterranean against several different major Greek kingdoms. They resulted in Roman control or influence over the eastern Mediterranean basin, in addition to their hegemony in the western Mediterranean after the Punic wars. Traditionally, the "Macedonian Wars" include the four wars with Macedonia, in addition to one war with the Seleucid Empire, and a final minor war with the Achaean League (which is often considered to be the final stage of the final Macedonian war). The most significant war was that fought with the Seleucid Empire, while the war with Macedonia was the second, and both of these wars effectively marked the end of these empires as major world powers, even though neither of them led immediately to overt Roman domination. Four separate wars were fought against the weaker power, Macedonia, due to its geographic proximity to Rome, though the last two of these wars were against haphazard insurrections rather than powerful armies. Roman influence gradually dissolved Macedonian independence and digested it into what was becoming a leading global empire. The outcome of the war with the now-deteriorating Seleucid Empire was ultimately fatal to it as well, though the growing influence of Parthia and Pontus prevented any additional conflicts between it and Rome.