Lysophospholipase
In enzymology, a lysophospholipase (EC3.1.1.5) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are 2-lysophosphatidylcholine and H2O, whereas its two products are glycerophosphocholine and carboxylate.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. This family consists of lysophospholipase / phospholipase B EC3.1.1.5 and cytosolic phospholipase A2 which also has a C2 domain IPR000008. Phospholipase B enzymes catalyse the release of fatty acids from lysophospholipids and are capable in vitro of hydrolyzing all phospholipids extractable from yeast cells. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca and selectively hydrolyses arachidonyl phospholipids, the aligned region corresponds the carboxy-terminal Ca-independent catalytic domain of the protein as discussed in.