吕珊德拉 （希腊语：Λυσανδρα; 生存于前三世纪），是托勒密一世与安提帕特之女欧律狄刻所生的女儿。

吕珊德拉第一次婚姻是与卡山德之子，同时也是马其顿国王的亚历山大五世结婚。当亚历山大五世逝世后，她改嫁给色雷斯国王利西马科斯之子阿加托克利斯，时间可能发生在前291年利西马科斯远征盖塔人之后。前284年，在受到利西马科斯之妻阿尔西诺伊挑拨下，她丈夫阿加托克利斯被利西马科斯的下令诛杀，她带着好几个孩子和阿加托克利斯之弟亚历山大逃到亚洲，寻求塞琉古一世帮助。塞琉古随后便与利西马科斯开战，并在库鲁佩迪安战役中击败利西马科斯。从保萨尼亚斯的描述，吕珊德拉应该在这段期间陪同塞琉古一世远征，并对他有相当的影响力，在几个月后塞琉古一世逝世后，不清楚吕珊德拉和她孩子以后的情况。

Lysandra (Greek: Λυσάνδρα, meaning "Liberator, Emancipator"; lived 3rd century BC) was a daughter of Ptolemy I Soter and Eurydice, a daughter of Antipater.

She was married first to her maternal cousin Alexander, one of the sons of Cassander, King of Macedonia. After Alexander’s death, Lysandra married her other maternal cousin Agathocles, the son of Lysimachus and Nicaea of Macedon. By this second marriage (which took place, according to Pausanias, after the return of Lysimachus from his expedition against the Getae, 291 BC) she had several children, with whom and with Agathocles' paternal half-brother Alexander she fled to Asia after the murder of her husband by Lysimachus, at the instigation of Agathocles’ stepmother Arsinoe II, and besought assistance from Seleucus I Nicator. The latter in consequence marched against Lysimachus, who was defeated and slain in the battle of Corupedium, 281 BC. From an expression of Pausanias, it appears that Lysandra must at this time have accompanied Seleucus I, and was possessed of much influence, but in the confusion that followed the death of Seleucus I a few months after there is no further record either of her or her children.