Luco dei Marsi is a comune and town in the Province of L'Aquila in the Abruzzo region of Italy. It is part of the Marsica.

The town was probably founded by the Roman Emperor Claudius to house workers in the drying of the Lacus Fucinus (Lake Fucino). The name derives from a nearby wood, Lucus Angitiae, "Sacred Grove of Angitia," referring to a divine sorceress of the Marsi Italic tribe.