Lomustine

Lomustine (INN), also called 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (trade name CeeNU in the U.S.) is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug and thus crosses the blood-brain barrier. This property makes it ideal for treating brain tumors, which is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).