革囊胃（Linitis Plastica），又称皮革胃，是由横向浸润生长的胃癌导致的一种胃部病态结构变化。因其特征之一为胃壁变厚、僵硬，外观类似皮革囊而得名。在进展期胃癌的形态分型中，革囊胃见于Borrmann 4型（弥漫浸润型胃癌）。

革囊胃见于一些低分化胃癌，肿瘤向胃壁内部浸润和弥漫生长的情况。肿瘤可先后浸润黏膜下层、肌层和浆膜层。这类肿瘤沿胃壁生长，可造成整个胃壁受侵。受侵胃壁组织发生纤维化，黏膜皱襞消失，胃壁本身变厚变硬，并造成胃蠕动减慢和胃腔缩小。

革囊胃病人可有食量差，易早饱等类似其他良性胃病的自觉症状，但也有时无自觉症状。因此其早期容易漏诊，很多到确诊的时候已经属于晚期胃癌。疑为革囊胃者，可以用钡餐检查来进一步确诊。

Linitis plastica, also known as Brinton's disease or leather bottle stomach, is a morphological variant of diffuse (or infiltrating) stomach cancer.

Causes of linitis plastica could be lye ingestion or metastatic infiltration of the stomach, particularly breast and lung carcinoma. It is not associated with H. pylori infection or chronic gastritis. The risk factors are undefined, except for rare inherited mutations in E-cadherin, which are found in about 50% of diffuse-type gastric carcinomas.