Nomifensine


![Nomifensine synthesis:[15][16] GB 1164192 corresp to G. Ehrhart et al., U.S. Patent 3,577,424 (1969, 1971, both to Hoechst).](/uploads/202501/24/Nomifensine_synthesis0612.png)
Nomifensine (Merital, Alival) is a norepinephrine-dopamine reuptake inhibitor, i.e. a drug that increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters. This is a mechanism of action shared by some recreational drugs like cocaine and the medication Tametraline (see DRI). Research showed that the (S) isomer is responsible for activity.