Under a microscope, Lewy bodies look like dark, eosinophilic inclusions inside the affected neurons.

光镜下，受累神经元内的路易小体看起来像是黑色的嗜酸性包涵体。

As the disease progresses, more and more neurons accumulate Lewy bodies and die.

随着病情的发展，越来越多的神经元因路易小体积聚而死亡。

After his death it was discovered what had been diagnosed as Parkinson's was actually Lewy body dementia.

在他去世后人们才发现，当初诊断的帕金森病实则是路易体痴呆。

The underlying cause of Lewy body dementia isn't well understood.

路易体痴呆的潜在病因尚不清楚。

The misfolded alpha-synuclein aggregates to form Lewy bodies that deposit inside neurons, particularly in the cortex and the substantia nigra.

错误折叠的α-突触核蛋白聚集形成路易小体，沉积在神经元中，尤其是在皮层和黑质中。

Lewy bodies refers to protein deposits found inside neurons, and they're named after Frederic Lewy, the neurologist who discovered them.

路易小体是指在神经元内发现的蛋白质沉积，以首次发现它们的神经学家弗雷德里克·路易的名字命名。

The function of alpha-synuclein is unknown, as well as the significance of Lewy bodies, and they are both found in other diseases like Lewy body dementia and multiple system atrophy.

α突触核蛋白的功能和路易小体的意义仍不清楚，它们也出现在了路易体痴呆和多系统萎缩等疾病中。

Normally, neurons contain a protein called alpha-synuclein, and in Lewy body dementia, this protein gets misfolded within the neurons.

正常情况下，神经元中含有一种叫作α-突触核蛋白的蛋白质；在路易体痴呆中，这种蛋白质在神经元中错误地折叠。

Under a microscope, Lewy bodies, which are eosinophilic, round inclusions made of alpha-synuclein protein are present in the affected substantia nigra neurons before they die.

显微镜下，路易小体——即由α突触核蛋白构成的嗜酸性包含体，可在受损的黑质神经元死亡前，于细胞内被观察到。

The significance of Lewy bodies, however, is unknown, but they're seen in other diseases like Parkinson's disease and multiple system atrophy.

然而，路易小体在其中的作用机制还不清楚，但它们也出现在了其它疾病中，如帕金森病、多系统萎缩。

A diagnosis of Lewy body dementia is based on the pattern of symptoms, but can only be confirmed with a brain autopsy that shows Lewy bodies in neurons.

路易体痴呆的诊断是基于症状，但只能通过脑活检，在神经元中发现路易小体来确诊。

Lewy body dementia is a neurodegenerative disease, meaning that it worsens over time, and it's the disease that afflicted comedian and actor Robin Williams.

路易体痴呆是一种神经退行性疾病，意味着病情会随着时间的推移而逐渐恶化；喜剧演员罗宾·威廉姆斯就是患上了这种疾病。

Lewy bodies are small clumps of proteins, mainly one called alpha-synuclein.

路易体是一小块蛋白质， 主要是一种叫做α- 突触核蛋白的蛋白质。

In Lewy body dementia, the early symptoms are typically cognitive ones, like difficulty focusing, poor memory, visual hallucinations, disorganized speech and depression, similar to Alzheimer's disease.

路易体痴呆的早期症状主要是认知方面的，比如注意力不集中、记忆力差、产生幻觉、说话混乱与抑郁等，类似于阿尔茨海默病。

They also did not see a delay in the first signs of Lewy bodies dementia, the disorder causes patients to see or experience things that do not real exist.

他们并没有发现和路易体痴呆首次出现的延迟，这种疾病能使病人看到或经历根本不存在的东西。

Robin Williams was not suffering from any of those advanced symptoms at the time of his death. Lewy bodies accumulate slowly, over years, with gradually worsening symptoms.

罗宾·威廉姆斯 (Robin Williams) 去世时并未出现任何这些晚期症状。多年来，路易体缓慢积累， 症状逐渐恶化。

So today we’re going to talk about Robin Williams, whose autopsy has shown that he was suffering from the early stages of a disease called Lewy body dementia.

所以今天我们要谈谈罗宾威廉姆斯，他的尸检表明他患有一种叫做路易体痴呆症的疾病的早期阶段。