These trials established letrozole as a standard treatment for people with this type of breast cancer, but not all patients benefit equally from the drug.

这些试验证实来曲唑是这类乳腺癌的标准治疗方法，但它对每个病人的疗效并不一样。

The novelty of their approach was that the women in question had each been involved in one of two clinical trials of a drug called letrozole.

但其方法的新颖之处是，他们还同时进行一种名为来曲唑的药物的临床试验。该试验有两种，每个病人都接受其中的一种。

Dr Ellis and his colleagues showed that those whose tumours carried mutations in p53 (16% of the total) were less likely to have responded to letrozole than women whose tumours had normal p53.

埃利斯博士等人证明了，来曲唑对肿瘤中有p53基因突变的病人（占总数的16%）的疗效不如对肿瘤中p53基因正常的病人那样显著。

In this, they were following the normal protocol of the cancer genome consortium.The novelty of their approach was that the women in question had each been involved in one of two clinical trials of a drug called letrozole.

他们在这一工作中是按癌症基因组协作组的标准程序操作的，但其方法的新颖之处是，他们还同时进行一种名为来曲唑的药物的临床试验。该试验有两种，每个病人都接受其中的一种。