Objective To study the efficacy and safety of leflunomide (LEF) in the treatment of active rheuma-toid arthritis (RA) compared to methotrexate (MTX).
摘要目的研究来氟米特治疗活动期类风湿关节炎的临床疗效和安全性。
Leflunomide
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Leflunomide
![Teriflunomide is the active metabolite of leflunomide, responsible for its therapeutic actions. It results from the reaction of isoxazole ring opening, which occurs in vivo. Teriflunomide then can interconvert between the E and Z enolic forms (and the corresponding keto-amide), with the Z-enol being the most stable and therefore most predominant form.[29][30]](/uploads/202501/23/Activation_of_leflunomide.svg3534.png)
Leflunomide (original brand name Arava) is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase.
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