And because glutamate sites become less effective, information flow becomes slow, and only the largest signals can make it through.
由于谷氨酸有效性减小，信息流动变缓，因此只有最强的信号可以通过。
英语百科
Large-signal model
（重定向自Large signal）
Large-signal modeling is a common analysis method used in electrical engineering to describe nonlinear devices in terms of the underlying nonlinear equations.
In circuits containing nonlinear elements such as transistors, diodes, and vacuum tubes, under "large signal conditions", AC signals have high enough magnitude that nonlinear effects must be considered.