| 单词 | Knockout study |
| 释义 |
Knockout study
中文百科
基因剔除 Gene knockout（重定向自Knockout study）
基因剔除（英语：gene knockout，暱称：KO）是指一种遗传工程技术，针对某个串行已知但功能未知的串行，改变生物的遗传基因，令特定的基因功能丧失作用，从而使部分功能被屏障，并可进一步对生物体造成影响，进而推测出该基因的生物学功能。 此技术是由马里奥·卡佩奇、马丁·埃文斯与奥利弗·史密斯所开发，最初是以基因剔除小鼠（knockout mouse，暱称：KO mouse）完成实验，三人并因此获得2007诺贝尔医学奖。
英语百科
Gene knockout 基因剔除（重定向自Knockout study）
 ![Wild-type Physcomitrella and knockout mosses: Deviating phenotypes induced in gene-disruption library transformants. Physcomitrella wild-type and transformed plants were grown on minimal Knop medium to induce differentiation and development of gametophores. For each plant, an overview (upper row; scale bar corresponds to 1 mm) and a close-up (bottom row; scale bar equals 0.5 mm) are shown. A: Haploid wild-type moss plant completely covered with leafy gametophores and close-up of wild-type leaf. B–D: Different mutants.[2]](/uploads/202501/22/Physcomitrella_knockout_mutants2147.JPG)   A gene knockout (abbreviation: KO) is a genetic technique in which one of an organism's genes is made inoperative ("knocked out" of the organism). Also known as knockout organisms or simply knockouts, they are used in learning about a gene that has been sequenced, but which has an unknown or incompletely known function. Researchers draw inferences from the difference between the knockout organism and normal individuals. |
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