霍皮奥尔河是俄罗斯的河流，也是顿河的左支流，河道全长979公里，流域面积61,100平方公里，河水阔度300米，323公里的河道可让船只航行。

霍皮奥尔河发源自奔萨西南，向西南转南流入顿河。

Khopyor (Russian:Хопёр, also transliterated as Khoper) is a river in European Russia, the biggest left tributary of the Don River. It is 979 kilometres (608 mi) long, with a watershed of 61,100 square kilometres (23,600 sq mi). The mouth width is 300 metres (980 ft). The Khopyor is navigable up to 323 kilometres (201 mi) from the mouth. The maximum discharge is 3,720 cubic metres per second (131,000 cu ft/s); the average discharge is 150 cubic metres per second (5,300 cu ft/s), and the minimum discharge is 45 cubic metres per second (1,600 cu ft/s).