肯塔基河（Kentucky River）是俄亥俄河在肯塔基州内的一条支流，全长418公里（260英里），流域面积18000平方公里，提供肯塔基州六分之一人口的饮用水。

肯塔基河有南北两源，北支肯塔基河长为270公里。发源于松木山脉(pine moutain)的西麓,在肯塔基东南部的阿巴拉契亚山脉中穿行，之后折向西北，接纳多条支流后，于李郡接纳发源于阿巴拉契亚山脉长169公里的中支肯塔基河，合流8公里后，在贝提维尔附近与发源子克雷郡，长72公里的南支肯塔基河汇合，流向西北方向。穿越丹尼尔·布恩国家森林，流经Irvine与Boonesborough，接纳红河等支流，折向西南，流经莱克星顿南部,然后北流穿越法兰克福，最后于卡罗顿汇入俄亥俄河。

The Kentucky River is a tributary of the Ohio River, 260 miles (418 km) long, in the U.S. Commonwealth of Kentucky. The river and its tributaries drain much of the central region of the state, with its upper course passing through the coal-mining regions of the Cumberland Mountains, and its lower course passing through the Bluegrass region in the north central part of the state. Its watershed encompasses about 7,000 square miles (18,000 km). It supplies drinking water to about one-sixth of the population of the Commonwealth of Kentucky.