约翰汉考克中心（John Hancock Center）是位于美国伊利诺伊州芝加哥的一幢摩天大楼，别名「BigJohn」，楼高343.5米（1,127英尺） ，加上天线更高达457.2米，地上100层，总楼面面积260,126平方米，开工于1965年，完工于1969年，是当时纽约之外全世界最高的摩天大楼。

约翰汉考克中心是现在芝加哥第3高和美国第4高的大楼，是由结构工程师法兹勒汗（Fazlur Khan）所设计。在大楼的94楼设有观景台，95楼设有餐厅，能饱览芝加哥和密西根湖的景色。 44楼设有一个全美国最高的室内游泳池。

The John Hancock Center is a 100-story, 1,127-foot (344 m) supertall skyscraper at 875 North Michigan Avenue, Chicago, Illinois, United States. It was constructed under the supervision of Skidmore, Owings and Merrill, with chief designer Bruce Graham and structural engineer Fazlur Khan. When the building topped out on May 6, 1968, it was the second tallest building in the world, the tallest outside New York City. It is currently the fourth-tallest building in Chicago and the seventh-tallest in the United States, after One World Trade Center, the Willis Tower, the Trump Tower Chicago, the Empire State Building, the Bank of America Tower, and the Aon Center. When measured to the top of its antenna masts, it stands at 1,506 feet (459 m). The building is home to offices and restaurants, as well as about 700 condominiums, and contains the third highest residence in the world, after the Trump Tower in Chicago and the Burj Khalifa in Dubai. The building was named for John Hancock Mutual Life Insurance Company, a developer and original tenant of the building,.