Isocitrate dehydrogenase

One active site on the Porcine NADP+ dependent enzyme (green).[3] Porcine enzyme is a homodimer and has another active site on the other side.

Catalytic mechanism of the breakdown of isocitrate into oxalosuccinate, then into a final product of alpha-ketuglutarate. The oxalosuccinate intermediate is hypothetical; it has never been observed in the decarboxylating version of the enzyme.[11]

Isocitrate dehydrogenase (IDH) (EC1.1.1.42) and (EC1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO₂. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP as a cofactor instead of NAD. They localize to the cytosol as well as the mitochondrion and peroxisome.

单词	Isocitrate dehydrogenase
释义	Isocitrate dehydrogenase 英语例句库 Moreover, the activities of isocitrate lyase and isocitrate dehydrogenase in the 0 P-treated cells were 1.48 and 0.75 times higher than in the control at day 8 of the treatment. 在第8 d，缺磷条件下的细胞异柠檬酸裂解酶活性和异柠檬酸脱氢酶活性分别是对照的1.48倍和75%。英语百科 Isocitrate dehydrogenase Isocitrate dehydrogenase (IDH) (EC1.1.1.42) and (EC1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO₂. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP as a cofactor instead of NAD. They localize to the cytosol as well as the mitochondrion and peroxisome.
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