Isili, Ìsili in sardinian language, is a comune (municipality) in the province of Cagliari, southern Sardinia, Italy, located about 60 kilometres (37mi) north of Cagliari in the Sarcidano traditional region.
Isili borders the following municipalities: Gergei, Gesturi, Laconi, Nuragus, Nurallao, Nurri, Serri, Villanova Tulo.