安条克一世（救主）（希腊语：Αντίοχος ό Σωτήρ，前324年－前261年），塞琉古帝国国王，前294年至前261年在位。

安条克一世是塞琉古帝国的创建者“胜利者”塞琉古一世和王后阿帕玛的儿子。约从前294年至前281年，他与父亲共同统治帝国，前281年父亲去世后开始独自统治，安条克一世在位期间，帝国接连陷入与马其顿王国安提柯二世的战争、安那托利亚的独立、托勒密王朝的叙利亚战争、加拉太人入侵和叙利亚境内叛乱，使安条克不得安宁。

安条克一世即位后，小亚细亚和叙利亚境内接连发生叛乱，安条克不得不停止与杀父仇人托勒密二世作战，被迫放弃色雷斯等地，也无法掌控对比提尼亚和卡帕多细亚波斯王公的控制。

Antiochus I Soter (Greek: Ἀντίοχος Α΄ ὁ Σωτήρ; epithet means "the Saviour"; c. 324/3 – 261 BC), was a king of the Hellenistic Seleucid Empire. He reigned in 281–261 BC.

Antiochus I was half Persian, his mother Apama being one of the eastern princesses whom Alexander the Great had given as wives to his generals in 324 BC. In 294 BC, prior to the death of his father Seleucus I, Antiochus married his stepmother, Stratonice, daughter of Demetrius Poliorcetes. His elderly father reportedly instigated the marriage after discovering that his son was in danger of dying of lovesickness. Stratonice bore five children to Antiochus: Seleucus (he was executed for rebellion), Laodice, Apama II, Stratonice of Macedon and Antiochus II Theos, who succeeded his father as king.