抗代谢物（英语：Antimetabolite）指化学结构与天然代谢产物相似的化合物，在代谢反应中能与正常代谢产物相拮抗，减少正常代谢物参与反应的机会，抑制正常代谢过程。

聚合酶链式反应抑制剂（阿糖胞苷）

核糖核苷酸还原酶抑制剂（吉西他滨）

亚硝脲类: 卡莫司汀 • 洛莫司汀（司莫司汀） • 福莫司汀 • 尼莫司汀 • 雷莫司汀 • 链脲佐菌素

烷基磺酸酯类: 白消安（甘露舒凡、苏消安）

医学导航: 肿瘤

基因/标志

肿瘤/同名/附瘤

药物 (L1i/1e/V03)

An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.