Probably because the hippocampus we talked about earlier is enriched with insulin receptors.

这可能是因为我们之前提到的海马体中富含胰岛素受体。

When those are filled up, insulin receptors decrease on those cells so glucose can't go in.

当细胞肝糖都储满了，胰岛素就会减少细胞上的受器，所以现在血糖无处可去了。

But when the blood-brain barrier is constantly flooded with insulin, it becomes resistant to it by downregulating insulin receptors.

但是，当血脑屏障一直“浸泡”在胰岛素中时，其胰岛素受体就会越发抵抗胰岛素。

Although ultimately unknown, the cause is thought to be related to pregnancy hormones that interfere with insulin's action on insulin receptors.

虽不清楚具体原因，目前认为与孕期的激素分泌相关，可能影响了胰岛素与胰岛素受体间的作用机制。

And, there are insulin receptors on the blood-brain barrier to get insulin into the brain so it can perform those functions.

这些功能，是由位于血脑屏障上的胰岛素受体将胰岛素送入大脑后完成的。

This ends up further damaging the liver and it promotes insulin resistance within the liver by inactivating IRS-1, that insulin receptor from before.

这进一步损害肝脏，还会通过灭活胰岛素受体 IRS-1 来促进胰岛素抗性。

Then, glucose is broken down and stored as triglycerides in the only place where insulin receptors are actually increasing your body fat.

然后，血糖再分解并储存成为三酸甘油酯，所以，胰岛素真的增加了你的脂肪。

The same JNK1 gets stimulated which promotes inflammation and JNK1 acts on the same IRS-1 insulin receptor causing insulin resistance in the liver.

和之前一样，JNK1 被激活，导致炎症。JNK1 作用于 IRS-1 受体，导致胰岛素抗性。

Is fat in the muscle, however it happened to get there, gumming up the insulin receptor lock and causing insulin resistance?

是肌肉中的脂肪碰巧塞住了细胞的胰岛素受体“锁孔”，从而导致胰岛素耐受症状的吗？

The insulin will stimulate this insulin receptor IRS-1, which causes a series of reactions to then stimulate SREBP1 and activate this enzyme called glucokinase.

胰岛素会刺激胰岛素受体 IRS-1，这会导致一系列的反应，从而刺激 SREBP1，并激活一个叫做葡萄糖激酶的酶。

Insulin reduces the amount of glucose in the blood by binding to insulin receptors embedded in the cell membrane of various insulin-responsive tissues like muscle cells and adipose tissue.

胰岛素通过和不同组织（如肌肉细胞和脂肪组织）细胞膜里的胰岛素受体结合，来减少血液中的血糖。

When activated, the insulin receptors cause vesicles containing glucose transporter that are inside the cell to fuse with the cell membrane, allowing glucose to be transported into the cell.

被激活时，胰岛素受体让细胞内含有葡萄糖转运蛋白的囊泡和细胞膜融合，使葡萄糖进入细胞内。

So, fat in the muscle may be associated with insulin resistance, but it's doubtful that it's the key cause of insulin resistance by gumming up the insulin receptor lock.

所以，肌肉中的脂肪可能与胰岛素耐受症状有关，但是否是导致这种耐受症状的关键因素尚不确定，尽管这些脂肪能堵塞细胞胰岛素受体“锁孔”。

This idea that fat from the diet is clogging up the insulin receptor leading to insulin resistance is what he's talking about within the first 10 minutes of Kip Andersen's relatively popular documentary " What the Health."

膳食脂肪阻碍细胞胰岛素受体，从而导致胰岛素耐受症状的观点，是他在 Kip Andersen《健康是什么》的纪录片中的前 10 分钟里表达的。