Inositol oxygenase

The active site of the mouse MIOX enzyme highlighting the di-iron active site along with the coordinated amino acids. The Fe atom binds to the oxygens of the C1 and C6 of myo-inositol. Lys 127 helps to promote the abstraction of the hydrogen atom from the C1 carbon.

The conversion of myo-inositol to glucaric acid--a top value-added chemical from biomass--can be achieved with a combination of MIOX and UDH enabling heterologous production of glucaric acid.

Inositol oxygenase, also commonly referred to as myo-inositol oxygenase (MIOX), is a non-heme di-iron enzyme that oxidizes myo-inositol to glucuronic acid. The enzyme employs a unique four-electron transfer at its Fe(II)/Fe(III) coordination sites and the reaction proceeds through the direct binding of myo-inositol followed by attack of the iron center by diatomic oxygen. This enzyme is part of the only known pathway for the catabolism of inositol in humans and is expressed primarily in the kidneys. Recent medical research regarding MIOX has focused on understanding its role in metabolic and kidney diseases such as diabetes, obesity and acute kidney injury. Industrially-focused engineering efforts are centered around improving MIOX activity in order to produce glucaric acid in heterologous hosts.

单词	Inositol oxygenase
释义	Inositol oxygenase 英语百科 Inositol oxygenase Inositol oxygenase, also commonly referred to as myo-inositol oxygenase (MIOX), is a non-heme di-iron enzyme that oxidizes myo-inositol to glucuronic acid. The enzyme employs a unique four-electron transfer at its Fe(II)/Fe(III) coordination sites and the reaction proceeds through the direct binding of myo-inositol followed by attack of the iron center by diatomic oxygen. This enzyme is part of the only known pathway for the catabolism of inositol in humans and is expressed primarily in the kidneys. Recent medical research regarding MIOX has focused on understanding its role in metabolic and kidney diseases such as diabetes, obesity and acute kidney injury. Industrially-focused engineering efforts are centered around improving MIOX activity in order to produce glucaric acid in heterologous hosts.
随便看	Isoprinosin的意思 ISOPRINOSINA的意思 Isoprinosine的意思 isopripyl chlorophenyl的意思 isoprobability plane的意思 isoprocarb的意思 isoprocil的意思 iso product curce的意思 isoprofen的意思 Isoprofenamine的意思 isoprofit的意思 isoprofit curves的意思 isoprofit line的意思 isoproic aldehydrogenase的意思 iso projection symbol的意思 isoprolactin B的意思 isopromedol的意思 isopromenthazine的意思 isopromethazine的意思 Isopropa,isoproturon的意思 isopropalin的意思 isopropaline的意思 isopropamide的意思 isopropamide bromide的意思 Isopropamide iodide的意思