免疫耐受（英语：immune tolerance或immunological tolerance）是指免疫系统对特定抗原的特异性无应答状态。免疫耐受包括天然免疫耐受与诱导免疫耐受。天然免疫耐受或自身耐受（self tolerance）是指机体对自身组织成分不产生免疫应答。诱导免疫耐受（induced tolerance）则是对外界抗原的免疫耐受，可以通过诱导方法产生。诱导免疫耐受可分为中枢耐受（central tolerance）、外周耐受（peripheral tolerance）与获得耐受（acquired tolerance）三种形式。

Immune tolerance or immunological tolerance describes a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response. It contrasts with conventional immune-mediated elimination of foreign antigens (see Immune response). Tolerance is classified into central tolerance or peripheral tolerance depending on where the state is originally induced—in the thymus and bone marrow (central) or in other tissues and lymph nodes (peripheral). The mechanisms by which these forms of tolerance are established are distinct, but the resulting effect is similar.