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单词 Hydroxydaunorubicin
释义

Hydroxydaunorubicin

中文百科

阿霉素 Doxorubicin

(重定向自Hydroxydaunorubicin)
两个与DNA作用的阿霉素分子。来自 PDB 1D12.[23]
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此错误不会显示于内文之中,仅会在预览时显示。

阿霉素Doxorubicin,又称hydroxyldaunorubicin多柔比星,商品名称是Adriamycin),是一种作用于DNA的药物,广泛使用于化学治疗。属于蒽环类(anthracycline)抗生素,结构与道诺霉素 (daunorubicin)相似,且与之同样能够对DNA发生嵌入作用。可用来治疗多种癌症。

此药物的给药方式为注射,市场上贩卖所使用的商品名称包括Adriamycin PFSAdriamycin RDFRubex

另有一种脂质体包覆的药剂,称为Doxil,生产者为强生公司,可减少心脏毒性(cardiotoxicity)。

英语百科

Doxorubicin 阿霉素

(重定向自Hydroxydaunorubicin)
Diagram of two doxorubicin molecules intercalating DNA, from PDB: 1D12​.[24]

Doxorubicin, sold under the trade names Adriamycin among others, is a medication used in cancer chemotherapy. It is derived by chemical semisynthesis from a bacterial species. It is an anthracycline antitumor antibiotic (note: in this context, this does not mean it is used to treat bacterial infections) closely related to the natural product daunomycin and like all anthracyclines, it works by intercalating DNA, with the most serious adverse effect being life-threatening heart damage. It is commonly used in the treatment of a wide range of cancers, including hematological malignancies (blood cancers, like leukaemia and lymphoma), many types of carcinoma (solid tumours) and soft tissue sarcomas. It is often used in combination chemotherapy as a component of various chemotherapy regimens.

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更新时间:2025/6/19 5:25:33