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单词 Hutchinson Gilford syndrome
释义

Hutchinson Gilford syndrome

英语百科

Progeria

 Potential therapeutic targets for the inhibition of progerin farnesylation
Confocal microscopy photographs of the descending aortas of two 15-month-old progeria mice, one untreated (left) and the other treated with the FTI drug tipifarnib (right)
Untreated cells from children with the genetic disease progeria (left) compared to similar cells treated with FTIs

Progeria (pronunciation: /prˈɪəriə/) (Hutchinson–Gilford progeria syndrome, HGPS, progeria syndrome) is an extremely rare genetic disorder in which symptoms resembling aspects of aging are manifested at a very early age. Progeria is one of several progeroid syndromes. The word progeria comes from the Greek words "pro" (πρό), meaning "before" or "premature", and "gēras" (γῆρας), meaning "old age". The disorder has a very low incidence rate, occurring in an estimated 1 per 8 million live births. Those born with progeria typically live to their mid teens to early twenties. It is a genetic condition that occurs as a new mutation, and is rarely inherited, as carriers usually do not live to reproduce. Although the term progeria applies strictly speaking to all diseases characterized by premature aging symptoms, and is often used as such, it is often applied specifically in reference to Hutchinson–Gilford progeria syndrome (HGPS).

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更新时间:2025/6/20 6:33:36